BVNS Neurotransmitter – CSM

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Cervical spondylomyelopathy (CSM) is often referred to as ‘Wobbler Syndrome.’
Why you may ask? Because affected dogs have a wobbly gait!

CSM is a disease that affects the cervical spine in large and giant breed dogs. The etiology is multifactorial and thought to represent a combination of genetic, nutritional, and degenerative causes. Important factors include congenital vertebral canal narrowing, vertebral body instability, disc degeneration and protrusion, joint capsule proliferation and osteophyte formation, and hypertrophy of the ligaments that surround the spinal cord. The most common clinical sign is a chronic, progressive gait disturbance which can range from mild to severe tetraparesis and proprioceptive ataxia affecting all 4 limbs. Cervical pain and low head carriage may also be seen.

There are 2 types of CSM recognized in dogs: Disc-associated and Joint-associated.

Disc-associated CSM is seen in middle aged to older large breed dogs; Doberman Pinschers are most often affected followed by Rottweilers and Bernese Mountain Dogs. Spinal cord compression most commonly occurs at C5-6 and C6-7 due to Type II disc degeneration and protrusion (leading to ventral compression); thickening of the vertebral ligaments and vertebral body instability may also contribute to cord compression.

• Joint or osseus-associated CSM is a disease of young adult giant breed dogs such as Great Danes and Mastiffs. Spinal cord compression usually occurs at C2-3 and C3-4 due to proliferation of the articular facet joints (leading to dorsolateral compression).

Imaging of the cervical spinal cord with an
MRI examination or a CT/myelogram study
demonstrates the location and extent of cervical
spinal cord compression. Lesions can also be
classified as dynamic (compressions that worsen
or improve with different neck positions) or

There are two treatment options for CSM: Conservative medical therapy and surgical treatment:

Medical therapy involves anti-inflammatory medication with prednisone or non-steroidal anti-inflammatory agents, physical therapy, periods of exercise restriction, and pain medication (often with gabapentin). Reports of success are variable; two large retrospective studies have found that between 45-54% of dogs treated medically improve in the short term; however, neurological deficits and pain progressed in the majority of affected dogs from both studies over the long term.1,2 Progression of disease may result in humane euthanasia due to poor patient quality of life and the difficulty for pet owners in trying to manage a large breed dog with limited mobility.

Surgical treatment may be recommended based on several factors including the degree of neck pain, severity of neurologic dysfunction, the degree of spinal cord compression seen on MRI examination, and lack of response to medical management. There are many different types of surgical techniques described and in some instances there may be a disparity in agreement as to which procedure carries the best outcome. The treatment for disc-associated CSM is typically ventral slot surgery at the site of disc protrusion (stabilization may be necessary in cases with dynamic compressions). For joint-associated CSM, decompression of the spinal cord via dorsal
laminectomy is most often performed. The majority of authors claim a 70-80% success rate with surgical therapy; therefore, the majority of surgically managed patients improve in the short term.3 However, over the long term, CSM can continue to progress in up to 50% of affected dogs in spite of surgical therapy again eventually resulting in poor patient and owner quality of life. This is due to several factors, most importantly, the development of spinal compression at other sites along the cervical spine (termed “adjacent segment disease”).


In summary, both medical and surgical treatment can benefit dogs with CSM in the short term. However, long term this disease has the potential to progress with either methodology. The choice of which treatment best suits each individual patient must take into account many factors; most importantly, the short and long term expectations of each individual owner must be taken into consideration so that an informed decision can be made on their dog’s behalf.


1 De Decker S et al. Clinical evaluation of 51 dogs treated conservatively for disc-associated wobbler syndrome. Journal Small Animal Practice.
2009; 50, 136-142.
2 Da Costa R, et al. Outcome of medical and surgical treatment in dogs with cervical spondylomyelopathy: 104 cases (1988-2004). 2008; 233(8),
3 Da Costa. Cervical Spondylomyelopathy (Wobbler Syndrome). Vet Clin North Am Small Anim Practice.2010 Sep;40(5):881-913.


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